Endocrine Abstracts

Introduction: Work-up of thyroid nodules remains challenging. Thyroid imaging reporting and data system (TIRADS) has been developed to improve patient management and cost-effectiveness by avoiding unnecessary fine needle aspiration biopsy (FNAB) in patients with thyroid nodules. However, since its publication in JCEM (2009) its clinical use is still very limited and its practicability in clinical practice is questioned. Realtime-elastography (RTE) enables the determination of ...

Introduction: Fibroblast growth factor-21 (FGF-21) is a novel regulator of glucose and lipid metabolism and insulin sensitivity. Possible role of FGF-21 in the development of insulin resistance in critically ill patients has not been studied yet.Objective: To study the changes in FGF21 production and adipose tissue and skeletal muscle FGF-21 mRNA gene expression in cardiac surgery patients.Methods: Sixteen patients (16 men, aged 66...

Objectives: To know the frequency of hypertension in a group of males with type two diabetes without the antecedent of hypertension, by means of ambulatory blood pressure monitoring (ABPM). To assess the possible differences between the subjects with and without hypertension in age, time of duration of diabetes, obesity and the features of metabolic syndrome.Methods: We included consecutively 55 males with type two diabetes without the antecedent of hype...

Acromegaly is associated with increased morbidity and mortality. Surgery, radiotherapy (RT) and medical therapy are the treatment options to decrease GH and IGF-I concentrations to levels associated with cure or normalisation of mortality. We examined the response to dopamine agonists (DA) and somatostatin analogues (SSA) in 276 patients with acromegaly who received medical therapy during follow up (198 DA, 143 SSA). One hundred and seventy two had surgery and 73 RT prior to m...

Acromegaly is associated with increased morbidity and mortality. There are several treatment options for acromegaly including surgery, radiotherapy and medical therapy. The aims of treatment in patients with acromegaly is to achieve GH and IGF-I concentrations associated with cure or normalisation of mortality.We examined predictive factors of response to treatment with dopamine agonists (DA) and somatostatin analogues (SSA) in a cohort of 501 patients w...

Objective: To reveal whether there are differences in serum level of retinol binding protein 4 (RBP4) in obese individuals with insulin resistance (IR) and without diabetes in comparison to those with 2 type diabetes mellitus (2 DM) treated by metformin and not obese controls.Methodology: The serum level of retinol binding protein 4 was examined by RIA method in 28 obese individuals with insulin resistance, 11 patients with 2 type diabetes mellitus treat...

Adipose tissue secreted hormonal mediators, adipokines play pivotal roles in the regulation of, among others, central nervous and immune systems influencing body weight, insulin action and inflammatory responses. The aim of our present study was to investigate possible associations of thyroid function with plasma levels of three of known adipokines, i.e. leptin, adiponectin and resistin in 74 Caucasian subjects without any endocrine diseases or related therapy. In order to cre...

A 57-year-old female patient was admitted for evaluation of multiple focal liver lesions diagnosed with abdominal ultrasound and CT. Her medical history included severe rheumatoid arthritis and pernicious anaemia treated with vitamin B12. Gastroscopic examination revealed numerous small polypoid lesions within the stomach, and histology of tissue samples obtained by biopsy showed carcinoid associated with atrophic gastritis. Although the patient had no symptoms of carcinoid sy...

Introduction: Treatment with sodium glucose co-transporter2(SGLT2) inhibitors was found to reduce the incidence of cardiovascular events in diabetic patients.Herein, we investigated the effects of long-term treatment with canagliflozin on atherosclerosis development in the aorta of Apolipoprotein E knockout (Apo-E(−/−)) mice as well as on biochemical and immunohistochemical markers related to atherosclerosis.Methods: At 4 weeks of ...

Acromegaly is a morbid condition mainly caused by overproduction of growth-hormone (GH) from a pituitary adenoma leading to excessive growth. Normalisation of insulin-like growth factor-1 (IGF1) is an important goal for the treatment of acromegaly. The second-generation somatostatin analog (SSA) long acting pasireotide (la-PAS) has recently been introduced for the management of patients uncontrolled by first-generation SSA. The ACRONIS study (CSOM230CIC05) will provide real-wo...